Open AccessAlimentary Tract Complications After Renal Transplantation
Author(s) -
William C. Meyers,
Norma Harris,
Susan Stein,
Margaret Brooks,
R. Scott Jones,
William M. Thompson,
Delford L. Stickel,
Hilliard F. Seigler
Publication year - 1979
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197910000-00013
Subject(s) - medicine , perforation , transplantation , diverticulitis , gastroenterology , disease , esophagitis , surgery , diverticular disease , gastrointestinal tract , kidney transplantation , peptic , peptic ulcer , reflux , materials science , punching , metallurgy
A computer analysis of post renal transplantation gastrointestinal problems was performed to identify important associated clinical factors. Thirty-seven per cent of all transplant recipients developed one or more significant problems. Hemorrhage, nondiverticular intestinal perforation, and esophagitis occurred most frequently in hospitalized patients. Pancreatitis, diverticulitis, and gastroduodenal perforation occurred characteristically in long-term survivors with well functioning allografts. Eleven of 32 HLA identical recipients treated with maintenance corticosteroids during stable kidney function developed gastrointestinal disease while only one of 13 HLA identical recipients not given maintenance steroids developed a problem, which strongly suggests a causal role for steroids in the development of late complications. The association of preexisting peptic ulcer and diverticular disease with hemorrhage and perforation supports previous recommendations that documented peptic ulcer disease or diverticulitis should be corrected surgically prior to transplantation.