Open AccessInfluence of Increasing Carbohydrate Intake on Glucose Kinetics in Injured Patients
Author(s) -
David H. Elwyn,
John M. Kinney,
Malayappa Jeevanandam,
Frank E. Gump,
J. Broell
Publication year - 1979
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197907000-00023
Subject(s) - medicine , endocrinology , glycogen , glucagon , gluconeogenesis , excretion , carbohydrate , carbohydrate metabolism , epinephrine , insulin , plasma glucose , metabolism
The metabolic and hormonal effect of glucose loads, ranging from 125 to 504 g/70 kg/day, were studied in severely injured patients. There was little or no correlation of glucose intake with nitrogen balance, plasma glucose, fatty acid concentrations, or epinephrine excretion. Increased norepinephrine excretion correlated with and may have resulted from increased glucose intake. Serum glucagon concentrations averaged 320 pg/ml and were not depressed by glucose intake. Insulin concentrations rose with glucose intake but were low for the level of plasma glucose. Glucose oxidation and non-oxidative metabolism, including glycogen deposition, correlated well with glucose intake. Gluconeogenesis from alanine was much higher than normal but was completely suppressed at very high intakes. The data imply that cycling of glucose, with glycerol, glycogen, or both, increased with increasing glucose intake.