Open AccessThe Effects of Metoclopramide on Postoperative Ileus A Randomized Double-blind Study
Author(s) -
Eugene D. Davidson,
Theodore Hersh,
Richard A. Brinner,
Stephen M. Barnett,
Lawrence P. Boyle
Publication year - 1979
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197907000-00006
Subject(s) - medicine , metoclopramide , laparotomy , ileus , anesthesia , nausea , randomized controlled trial , placebo , surgery , anastomosis , postoperative ileus , abdominal surgery , vomiting , alternative medicine , pathology
Metoclopramide or placebo was administered postoperatively in a randomized, double-blind fashion to 115 patients undergoing laparotomy. The effect of metoclopramide on postoperative adynamic ileus (PAI) was evaluated. The patients were stratified into two groups: Group A--those with laparotomy without a gastrointestinal anastomosis or ostomy procedure, and group B--those with laparotomy undergoing an anastomosis or ostomy procedure. Metoclopramide reduced nausea and emesis postoperatively. However, the only significant effect on postoperative adynamic ileus was an earlier return to tolerance of solid foods in the patients in Group A.