Open AccessJejunal Inhibition of Gastric Acid Secretion Induced by Hypertonic Glucose in Duodenal Ulcer Patients Before and After Truncal Vagotomy
Author(s) -
John Christiansen,
Peter Aagaard,
TH Hansen
Publication year - 1978
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197802000-00004
Subject(s) - pentagastrin , medicine , tonicity , gastric acid , vagotomy , secretion , duodenal ulcer , endocrinology , gastroenterology , microgram , sham feeding , biochemistry , biology , in vitro
The effect of intrajejunal infusion of hypertonic glucose on pentagastrin-stimulated (0.5 microgram/kg-hr) gastric acid secretion was studied in eight duodenal ulcer patients before and three to five months after truncal vagotomy. Preoperatively mean acid output was reduced from 44.0 +/- 3.1 meq H+/hr to 29.2 +/- 2.9 meq H+/hr (p less than 0.05), whereas no consistent changes were found postoperatively, suggesting that jejunal inhibition of gastric acid secretion induced by hypertonic glucose primarily is under vegal control. Furthermore, the study shows that glucose induced jejunal inhibition of acid secretion seems to be less pronouced in duodenal ulcer patients than previously found in healthy subjects.