Open AccessAn Analysis of Cytomegalovirus Infection and HLA Antigen Matching on the Outcome of Renal Transplantation
Author(s) -
Allyn G. May,
Robert F. Betts,
Richard B. Freeman,
Carl H. Andrus
Publication year - 1978
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197802000-00002
Subject(s) - medicine , cytomegalovirus , human leukocyte antigen , immunology , antigen , transplantation , kidney transplantation , incidence (geometry) , cytomegalovirus infection , betaherpesvirinae , histocompatibility , herpesviridae , human cytomegalovirus , viral disease , virus , physics , optics
Eighty-five recipients and donors of renal allografts were examined for evidence of cytomegalovirus infection before and repeatedly after transplantation. The recipients were also divided into two group on the basis of HLA antigen matching. Better allograft survival was noted in patients well matched for HLA antigens (0-2) mismatched antigens) compared to those poorly matched (three or more antigens mismatched), and in patients free of cytomegalovirus compared to those infected. Cytomegalovirus infection had a more marked influence on allograft survival than did HLA antigen matching. The differing rates of success of transplantation, apparently dependent on blood relationship between donor and recipient, have been assumed largely to be due to inherited factors. This study, however, revealed an important factor to be the disparate incidence of cytomegalovirus infection in sibling, parental, and cadaveric categories of transplantation. The mechanism of this disparity can be explained on the basis of the incidence of latent CMV infection in the recipients and various categories of kidney donors.