Open AccessDoes Adrenergic Activity Suppress Insulin Secretion During Surgery?
Author(s) -
M Aärimaa,
Erkka Syvälahti,
Jari Ovaska
Publication year - 1978
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197801000-00013
Subject(s) - medicine , insulin , adrenergic , halothane , endocrinology , adrenergic receptor , alpha (finance) , receptor , beta (programming language) , secretion , alpha 2 adrenergic receptor , anesthesia , surgery , construct validity , computer science , patient satisfaction , programming language
Peroperative inhibition of insulin release is widely attributed to increased alpha-adrenergic activity. To test this hypothesis serum insulin and glucose concentrations were measured at short intervals in 11 patients who underwent major surgery. Five patients were anesthetized with halothane and six with general anesthesia without halothane. The results were similar in both patient groups; halothane had no effect on insulin. This suggests that suppression of insulin under operations is probably not due to activation of the alpha-adrenergic receptors of the pancreatic beta-cells. The authors propose that suppression of insulin secretion during surgery may be caused by adrenaline, which, in competing for the glucose receptors, insensitizes the pancreatic beta-cells.