Open AccessGastric Ulceration in Patients Receiving Intrahepatic Infusion of 5-Fluorouracil
Author(s) -
Thomas Narsete,
Fred J. Ansfield,
George W. Wirtanen,
Guillermo Ramírez,
William H. Wolberg,
Fredric Jarrett
Publication year - 1977
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197712000-00012
Subject(s) - medicine , asymptomatic , epigastric pain , vomiting , stomach , surgery , catheter , perforation , etiology , gastroenterology , chemotherapy , materials science , punching , metallurgy
Gastric ulceration developed in eight patients during intrahpeatic arterial infusion of 5-FU. Bleeding occurred in four instances and perforation in one. In all cases the catheter tip had been dislodged and was proximal to its correct position, allowing the stomach to be directly infused with 5-FU. No duodenal ulcers were noted. All patients were symptomatic for several days before the diagnosis was made. Of 20 patients with catheter dislodgement, five had documented ulcers, three had upper gastrointestinal bleeding of undetermined etiology, eight had epigastric pain or vomiting and only four were asymptomatic. Prompt determination of catheter position is necessary in patients receiving intrahepatic arterial infusion of 5-FU if symptoms consistent with gastric ulceration occur. Gastric ulcers should be vigorously treated because of the high rate of complications in patients receiving chemotherapy.