Open AccessFat Induced Jejunal Inhibition of Gastric Acid Secretion in Duodenal Ulcer Patients Before and After Truncal Vagotomy
Author(s) -
John Christiansen
Publication year - 1977
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197711000-00005
Subject(s) - medicine , pentagastrin , gastroenterology , gastric acid , vagotomy , duodenal ulcer , secretion , sham feeding , endocrinology
The effect of intrajejunal infusion of a fat solution on pentagastrin-stimulated (0.5 microgram/kg-hr) gastric acid secretion was studied in five duodenal ulcer patients before and three to five months after truncal vagotomy. Preoperatively mean acid output was reduced from 41 +/- 5.2 meq H+/hr to 15.4 +/- 1.3 meq H+/hr (p less than 0.005), and postoperatively from 17.4 +/- 2.6 meq H+/hr to 12.7 +/- 2.4 meq H+/HR (P less than 0.01), demonstrating that fat induced jejunal inhibition of gastric acid secretion partly or wholly is humorally mediated. Furthermore the study shows that fat induced jejunal inhibition of acid secretion in duodenal ulcer patients seem to be of the same magnitude as previously found in healthy subjects.