Open AccessThe Surgeon, Genetics, and Cancer Control
Author(s) -
Henry T. Lynch,
Randall E. Harris,
Claude H. Organ,
Helmy M. Guirgis,
Patrick M. Lynch,
Jane F. Lynch,
Elizabeth M. Nelson
Publication year - 1977
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197704000-00011
Subject(s) - medicine , lynch syndrome , colorectal cancer , cancer , endometrial cancer , cancer genetics , cancer prevention , genetic counseling , general surgery , gynecology , genetics , dna mismatch repair , biology
A family manifesting the Cancer Family Syndrome has been evaluated extensively from the medical and genetic standpoint. Findings of excess occurrence of carcinoma of the colon and endometrium, multiple primary cancer, early age of onset, and autosomal dominant mode of genetic transmission mandate a program of increased surveillance and cancer education. Prophylactic surgical implications are provided for certain of these enormously high cancer risk patients.