Open AccessSuppression of Gastrin Release and Gastric Secretion by Gastric Inhibitory Polypeptide (GIP) and Vasoactive Intestinal Polypeptide (VIP)
Author(s) -
Hugo V. Villar,
H. Roberts Fender,
Phillip L. Rayford,
Stephen R. Bloom,
N I Ramus,
James C. Thompson
Publication year - 1976
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197607000-00016
Subject(s) - vasoactive intestinal peptide , gastrin , gastric inhibitory polypeptide , medicine , secretin , endocrinology , radioimmunoassay , glucagon , gastrointestinal hormone , basal (medicine) , gastric acid , secretin family , pancreatic polypeptide , secretion , peptide hormone , hormone , neuropeptide , insulin , receptor
Five dogs prepared with Heidenhain pouches received infusions of saline, GIP and VIP before and after a standard meat meal. Blood samples were obtained under basal conditions and at subsequent intervals for measurement of gastrin, insulin, GIP and VIP by radioimmunoassay. GIP and VIP infusions had no effect on basal levels of gastrin. GIP and VIP (in common with secretin and glucagon) were found to suppress food-stimulated release of gastrin and gastrin-stimulated acid secretion from the Heidenhain pouch. Insulin levels were significantly elevated during GIP and VIP infusions. Food released GIP (and perhaps VIP.