Open AccessEstrogen Receptor and Natural Course of Breast Cancer
Author(s) -
Amnuay Singhakowinta,
Henry G. Potter,
T. Buroker,
Bohumil A. Samal,
S.C. Brooks,
Vainutis K. Vaitkevicius
Publication year - 1976
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197601000-00017
Subject(s) - medicine , estrogen receptor , breast cancer , cancer , estrogen , oncology , metastatic breast cancer
The tumors from approximately 50% of patients with breast cancer contained estrogen receptor (ER). ER appeared more often and at higher levels in the tumors of postmenopausal women. Eleven out of 12 patients who had multiple ER assays from various metastatic sites showed no significant discrepancies in ER values. ER level appears to decrease as the duration of metastatic cancer increase. Patients with ER in the tumor more frequently have bone metastases than those without ER. Visceral metastases occurred more often with ER negative patients and appeared to have a more malignant course with significant shorter survival.