Open AccessMetiamide
Author(s) -
Magee Df
Publication year - 1975
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197511000-00015
Subject(s) - metiamide , pentagastrin , pepsin , histamine , medicine , stimulation , endocrinology , gastric acid , secretin , stomach , pilocarpine , receptor , secretion , chemistry , biochemistry , histamine h2 receptor , enzyme , antagonist , psychiatry , epilepsy
Metiamide, 25 mg, antagonized the action of histamine on acid and pepsin secretion from both denervated pouches and innervated stomachs in dogs. In the same preparations its action on pepsin following food, pentagastrin or 2 deoxy-d-glucose was nonsignificant. Following pilocarpine or secretin, metiamide augmented pouch pepsin. The action of every acid stimulant was depressed by metiamide including the direct vagal action of deoxy-d-glucose on the innervated stomach. H2 receptors seem, therefore, to be involved in some form in acid stimulated by the vagi, histamine, pentagastrin and pilocarpine. Pepsin stimulation does not seem to be via H2 receptors with the esception of stimulation by histamine itself.