Open AccessSepsis, Resuscitated Hemorrhagic Shock and “Shock Lung“
Author(s) -
Barry C. Esrig,
Robert L. Fulton
Publication year - 1975
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197509000-00005
Subject(s) - medicine , shock (circulatory) , hypoxemia , lung , resuscitation , sepsis , pulmonary compliance , respiratory failure , anesthesia , intensive care medicine
Dogs were submitted to hermorrhagic shock, resuscitated shock and resuscitated shock plus a pulmonary bacterial insult. Pulmonary familure was absent in dogs submitted only to shock or to shock and its resuscitation. The addition of usually sub-lethal amounts of micro-organisms to the shock-resuscitated lung caused rapid death from pulmonary failure. Pulmonary failure was demonstrated by increased lung weight, hypoxemia, decreased compliance and a hemorrhagic destruction of lung tissue. These findings strongly support recent concepts of an infective genesis of "shock lung" in man.