Open AccessHeidenhain Pouch distension as a Stimulus for Acid and Pepsin Secretion
Author(s) -
D. F. Magee,
Chien-Yeh Hu
Publication year - 1975
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197508000-00006
Subject(s) - pepsin , pentagastrin , medicine , atropine , distension , saline , pouch , gastric acid , sham feeding , endocrinology , secretion , anatomy , biochemistry , chemistry , enzyme
Heidenhain pouches, in dogs with simple gastric fistulae, were distended with saline (30, 60 and 90 ml). Pouch acid and pepsin increased linearly with increasing saline volume. Additional pentagastrin augmented the acid but antagonized the pepsin responses. Atropine depressed both the acid and pepsin responses to distention. Ganglionic blockade and local anesthetization of the secretory mucosa also depressed the acid but spared the pepsin response.