Open AccessFactors Determining Successful Liver Preservation for Transplantation
Author(s) -
Luis H. ToledoPereyra,
Richard L. Simmons,
John S. Najarían
Publication year - 1975
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197503000-00008
Subject(s) - medicine , pulsatile flow , liver transplantation , methylprednisolone , perfusion , potassium , transplantation , surgery , anesthesia , chemistry , organic chemistry
Auxiliary liver allotransplants will survive for relatively long periods of time after 24 hour hypothermic (10-12C), pulsatile perfusion. The best perfusate was a silica gel fraction of dog plasma with added potassium chloride gel made hyperosmolar with glucose. Further improvement could be achieved with added allopurinol and methylprednisolone. Nonpulsatile flow or lower temperatures were less effective preservation techniques.