Open AccessErythrocyte 2, 3-Diphosphoglycerate in Endotoxic Shock in the Subhuman Primate
Author(s) -
George Johnson,
Noel B. McDevitt,
H. J. Proctor
Publication year - 1974
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197411000-00013
Subject(s) - endotoxic shock , diphosphoglycerate , baboon , hemodynamics , medicine , shock (circulatory) , escherichia coli , endocrinology , biology , biochemistry , hemoglobin , gene
The effects of shock as a result of Escherichia coli endotoxin on certain hemodynamic and biochemical parameters and mortality were studied in the baboon. The ability of methylprednisolone succinate (MPS) in massive doses and/or rapid infusion of a buffered electrolyte solution to influence the results was then examined. Shock secondary to Escherichia coli endotoxin was associated with a decrease in RBC 2,3-DPG. This fall in RBC 2,3-DPG was not significantly influenced by MPS. Likewise, MPS did not prevent the changes in oxygen metabolism or systemic hemodynamics, nor was it associated with any decrease in mortality associated with endotoxic shock. Buffered electrolyte solution therapy improved both hemodynamics and mortality, but did not significantly protect against changes in RBC 2,3-DPG.