Open AccessIncreased Oxyhemoglobin Affinity After Transfusion of Stored Blood
Author(s) -
John C. Bowen,
William H. Fleming
Publication year - 1974
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197411000-00009
Subject(s) - medicine , oxygen , arteriovenous oxygen difference , oxygen tension , significant difference , blood flow , oxygen delivery , anesthesia , venous blood , cardiology , blood pressure , heart rate , chemistry , stroke volume , organic chemistry
The effect of change in red cell 2,3-diphosphoglycerate concentration after transfusion of ACD stored blood on arteriovenous oxygen content difference, arteriovenous oxygen tension difference and oxygen consumption was assessed in 15 injured patients in Vietnam. A significant increase in the arteriovenous oxygen tension difference and oxygen consumption was observed at the time of low 2,3-DPG. Change in 2,3-DPG did not correlate, however, with change in either arteriovenous oxygen content difference or venous PO(2). This study suggests that alterations in oxyhemoglobin affinity are effectively compensated, possibly by opening capillaries to increase blood flow to tissues, by reducing the capillary-tissue oxygen gradient to maintain the rate of tissue oxygen extraction, or by increasing cardiac output.