Open AccessAlpha Fetoprotein
Author(s) -
Leon C. Parks,
Alan N. Baer,
Megan Pollack,
G M Williams
Publication year - 1974
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197410000-00025
Subject(s) - medicine , alpha fetoprotein , clearance , immunotherapy , cancer , cancer research , pathology , oncology , immunology , hepatocellular carcinoma , urology
CLINICAL AND LABORATORY STUDIES OF AFP PRODUCING HEPATOMAS DEMONSTRATED THAT: 1) serum AFP levels correlated directly with tumor growth; 2) circulating AFP could be cleared by passive administration of an. excess of anti-AFP; and 3) highly specific anti-AFP functioned as a carrier to localize diagnostic and possibly therapeutic amounts of radioactivity in hepatoma tissue. These studies helped elucidate certain criteria which should be fulfilled before attempts to initiate passive humoral immunotherapy of cancer are undertaken.