Open AccessGastrin Release by Ethanol in Man and in Dogs
Author(s) -
H. D. Becker,
David D. Reeder,
James C. Thompson
Publication year - 1974
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/00000658-197406000-00015
Subject(s) - gastrin , medicine , antrum , radioimmunoassay , perfusion , endocrinology , g cell , ethanol , pyloric antrum , stomach , secretion , biochemistry , chemistry
In man, oral or intravenous administration of ethanol caused a small but definite increase in peripheral serum gastrin concentration (measured by radioimmunoassay). In dogs, perfusion of the antrum with 10% ethanol caused an immediate increase in gastrin levels in the antral venous outflow. Acidification of the perfusate did not totally block the gastrin release from the antrum. Intravenous infusion of ethanol in dogs caused release of gastrin from the antrum.