Open AccessThe Effect of Fluoride and Hypothermia on the In Vitro Metabolism of Mivacurium
Author(s) -
Michael Gruber,
Regina Lindner,
Christopher Prasser,
Gunther Wiesner
Publication year - 2002
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1097/00000539-200208000-00029
Subject(s) - medicine , in vitro , in vivo , fluoride , cis–trans isomerism , ed50 , enzyme , metabolism , pharmacology , anesthesia , stereochemistry , biochemistry , chemistry , receptor , biology , inorganic chemistry , microbiology and biotechnology
The fluoride inhibition of mivacurium hydrolysis by pseudocholinesterase increases in hypothermia, but it will very rarely occur in clinical practice because it requires rather large fluoride concentrations (>50 micromol/L) and very low temperatures (<28 degrees C).