Open AccessThe Effects of Increasing Concentrations of Isoflurane and Desflurane on Pulmonary Perfusion and Systemic Oxygenation During One-Lung Ventilation in Pigs
Author(s) -
Konrad Schwarzkopf,
Torsten Schreiber,
Reinhard Bauer,
Harald Schubert,
Niels-Peter Preussler,
Elke Gaser,
U. Klein,
Waheedullah Karzai
Publication year - 2001
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1097/00000539-200112000-00017
Subject(s) - medicine , desflurane , isoflurane , anesthesia , hypoxic pulmonary vasoconstriction , oxygenation , perfusion , lung , pulmonary shunt , ventilation (architecture) , hemodynamics , cardiology , vasoconstriction , mechanical engineering , engineering
During one-lung ventilation (OLV), hypoxic pulmonary vasoconstriction (HPV) reduces venous admixture and attenuates the decrease in arterial oxygen tension by diverting blood from the nonventilated lung to the ventilated lung. In vitro, desflurane and isoflurane depress HPV in a dose-dependent manner. Accordingly, we studied the effects of increasing concentrations of desflurane and isoflurane on pulmonary perfusion, shunt fraction, and PaO(2) during OLV in vivo. Fourteen pigs (30-42 kg) were anesthetized, tracheally intubated, and mechanically ventilated. After placement of femoral arterial and thermodilution pulmonary artery catheters, a left-sided double-lumen tube (DLT) was placed via tracheotomy. After DLT placement, FIO(2) was adjusted at 0.8 and anesthesia was continued in random order with 3 concentrations (0.5, 1.0, and 1.5 minimal alveolar concentrations) of either desflurane or isoflurane. Differential lung perfusion was measured with colored microspheres. All measurements were made after stabilization at each concentration. Whereas mixed venous PO(2), mean arterial pressure, cardiac output, nonventilated lung perfusion, and shunt fraction decreased in a dose-dependent manner, PaO(2) remained unchanged with increasing concentrations of desflurane and isoflurane during OLV. In conclusion, increasing concentration of desflurane and isoflurane did not impair oxygenation during OLV in pigs.