Open AccessMalignant Eccrine Spiradenoma
Author(s) -
Zsolt B. Argényi,
Anh Thi Van Nguyen,
Károly Balogh,
Joel K. Sears,
Duane C. Whitaker
Publication year - 1992
Publication title -
the american journal of dermatopathology/american journal of dermatopathology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.454
H-Index - 73
eISSN - 1533-0311
pISSN - 0193-1091
DOI - 10.1097/00000372-199210000-00002
Subject(s) - pathology , immunohistochemistry , scalp , medicine , malignant transformation , trichoepithelioma , biology , basal cell , dermatology , basal cell carcinoma
Malignant eccrine spiradenomas (MES) are exceedingly rare and their immunohistochemical and ultrastructural features have not been fully characterized. We studied two cases, one of them immunohistochemically and electron microscopically. Patient 1 had a 25-year history of multiple exophytic tumors involving the scalp, the skin of the face, and the torso. Of the lesions removed, ten were spiradenomas, two with malignant changes, and three were cylindromas. The malignant areas showed loss of tubular and nesting patterns, lack of two cell populations, and contained anaplastic cells with high mitotic rate. The immunohistochemical findings were consistent with eccrine differentiation. Patient 2 had a cystlike mass of long duration in the right groin. Histologically, the mass consisted of nodules of benign eccrine spiradenomas adjacent to a ductal-cystic mass lined by anaplastic cells, but areas of squamous and glandular differentiation were also present.