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Prosaptide™D5, a retro‐inverso 11‐mer peptidomimetic, rescued dopaminergic neurons in a model of Parkinson's disease
Author(s) -
Liu Jian,
Wang Cui Ying,
O'Brien John S.
Publication year - 2001
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fsb2fj000603fje
Subject(s) - dopaminergic , peptidomimetic , substantia nigra , neurite , parkinson's disease , dopamine , mptp , pharmacology , chemistry , neuroscience , biology , medicine , in vitro , disease , biochemistry , peptide
In this report we present a novel strategy for the rescue of dopaminergic neurons in a Parkinson's disease (PD) model by using a bioactive protease resistant RETRO‐INVERSO trophic peptidomimetic derived from prosaposin, Prosaptide™D5. When injected subcutaneously in mice with MPTP toxicity, Prosaptide™D5 treatment rescued DA neurons in the substantia nigra; the rescue was complete 15 days after treatment. Treatment with Prosaptide™D5 also rescued neurons from cell death IN VITRO by increasing neurite sprouting and by normalizing dopamine (DA) uptake. Prosaptide™D5 is a unique peptidomimetic trophic factor that has been shown to be effective on a PD model when given systemically.