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Linker histone binding and displacement: versatile mechanism for transcriptional regulation
Author(s) -
Zlatanova Jordanka,
Caiafa Paola,
Van Holde Kensal
Publication year - 2000
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.99-0869rev
Subject(s) - nucleosome , chromatin , histone , linker , transcriptional regulation , linker dna , microbiology and biotechnology , chemistry , chromatosome , histone code , dna , biophysics , transcription factor , biology , biochemistry , gene , computer science , operating system
In recent years, the connection between chromatin structure and its transcriptional activity has attracted considerable experimental effort. The post‐translational modifications to both the core histones and the linker histones are finely tuned through interactions with transcriptional regulators and change chromatin structure in a way to allow transcription to occur. Here we review evidence for the involvement of linker histones in transcriptional regulation and suggest a scenario in which the reversible and controllable binding/displacement of proteins of this class to the nucleosome entry/exit point determine the accessibility of the nucleosomal DNA to the transcriptional machinery.—Zlatanova, J., Caiafa, P., van Holde, K. Linker histone binding and displacement: versatile mechanism for transcriptional regulation. FASEB J. 14, 1697–1704 (2000)