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The role of endocrine hormones in the pathogenesis of adolescent idiopathic scoliosis
Author(s) -
Liang ZhuoTao,
Guo ChaoFeng,
Li Jiong,
Zhang HongQi
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.202100759r
Subject(s) - hormone , endocrine system , scoliosis , leptin , idiopathic scoliosis , medicine , pathogenesis , estrogen , physiology , endocrinology , bioinformatics , biology , obesity , surgery
Abstract Adolescent idiopathic scoliosis (AIS) is a common spinal deformity characterized by changes in the three‐dimensional structure of the spine. It usually initiates during puberty, the peak period of human growth when the secretion of numerous hormones is changing, and it is more common in females than in males. Accumulating evidence shows that the abnormal levels of many hormones including estrogen, melatonin, growth hormone, leptin, adiponectin and ghrelin, may be related to the occurrence and development of AIS. The purpose of this review is to provide a summary and critique of the research published on each hormone over the past 20 years, and to highlight areas for future study. It is hoped that the presentation will help provide a better understanding of the role of endocrine hormones in the pathogenesis of AIS.