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Placentas delivered by pre‐pregnant obese women have reduced abundance and diversity in the microbiome
Author(s) -
Benny Paula A.,
AlAkwaa Fadhl M.,
Dirkx Corbin,
Schlueter Ryan J.,
Wolfgruber Thomas K.,
Chern Ingrid Y.,
Hoops Suzie,
Knights Dan,
Garmire Lana X.
Publication year - 2021
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.202002184rr
Subject(s) - microbiome , diversity (politics) , abundance (ecology) , obstetrics , pregnancy , medicine , physiology , biology , bioinformatics , ecology , genetics , sociology , anthropology
Maternal pre‐pregnancy obesity may have an impact on both maternal and fetal health. We examined the microbiome recovered from placentas in a multi‐ethnic maternal pre‐pregnant obesity cohort, through an optimized microbiome protocol to enrich low bacterial biomass samples. We found that the microbiomes recovered from the placentas of obese pre‐pregnant mothers are less abundant and less diverse when compared to those from mothers of normal pre‐pregnancy weight. Microbiome richness also decreases from the maternal side to the fetal side, demonstrating heterogeneity by geolocation within the placenta. In summary, our study shows that the microbiomes recovered from the placentas are associated with pre‐pregnancy obesity. Importance Maternal pre‐pregnancy obesity may have an impact on both maternal and fetal health. The placenta is an important organ at the interface of the mother and fetus, and supplies nutrients to the fetus. We report that the microbiomes enriched from the placentas of obese pre‐pregnant mothers are less abundant and less diverse when compared to those from mothers of normal pre‐pregnancy weight. More over, the microbiomes also vary by geolocation within the placenta.