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The interaction partners of (pro)renin receptor in the distal nephron
Author(s) -
Chen Yanting,
Xu Chuanming
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.202001711r
Subject(s) - nephron , renin–angiotensin system , endocrinology , receptor , medicine , chemistry , kidney , blood pressure
The (pro)renin receptor (PRR), a key regulator of intrarenal renin‐angiotensin system (RAS), is predominantly presented in podocytes, proximal tubules, distal convoluted tubules, and the apical membrane of collecting duct A‐type intercalated cells, and plays a crucial role in hypertension, cardiovascular disease, kidney disease, and fluid homeostasis. In addition to its well‐known renin‐regulatory function, increasing evidence suggests PRR can also act in a variety of intracellular signaling cascades independently of RAS in the renal medulla, including Wnt/β‐catenin signaling, cyclooxygenase‐2 (COX‐2)/prostaglandin E 2 (PGE 2 ) signaling, and the apelinergic system, and work as a component of the vacuolar H + ‐ATPase. PRR and these pathways regulate the expression/activity of each other that controlling blood pressure and renal functions. In this review, we highlight recent findings regarding the antagonistic interaction between PRR and ELABELA/apelin, the mutually stimulatory relationship between PRR and COX‐2/PGE 2 or Wnt/β‐catenin signaling in the renal medulla, and their involvement in the regulation of intrarenal RAS thereby control blood pressure, renal injury, and urine concentrating ability in health and patho‐physiological conditions. We also highlight the latest progress in the involvement of PRR for the vacuolar H + ‐ATPase activity.