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Mitochondrial spare respiratory capacity: Mechanisms, regulation, and significance in non‐transformed and cancer cells
Author(s) -
Marchetti Philippe,
Fovez Quentin,
Germain Nicolas,
Khamari Raeeka,
Kluza Jérôme
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.202000767r
Subject(s) - mitochondrion , bioenergetics , adaptation (eye) , biology , spare part , function (biology) , microbiology and biotechnology , neuroscience , business , marketing
Abstract Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain bioenergetic levels related to cellular functions. This absence of proper adaptation can be seen in a wide array of conditions, including cancer. Metabolic adaptation calls on mitochondrial function and draws on the mitochondrial reserve to meet increasing needs. Among mitochondrial respiratory parameters, the spare respiratory capacity (SRC) represents a particularly robust functional parameter to evaluate mitochondrial reserve. We provide an overview of potential SRC mechanisms and regulation with a focus on its particular significance in cancer cells.