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Cancer cells display increased migration and deformability in pace with metastatic progression
Author(s) -
Liu Zhenhui,
Lee Se Jong,
Park Seungman,
Konstantopoulos Konstantinos,
Glunde Kristine,
Chen Yun,
Barman Ishan
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.202000101rr
Subject(s) - gerontology , medicine , library science , computer science
In this study, we explored the relation between metastatic states vs the capacity of confined migration, amoeboid transition, and cellular stiffness. We compared across an isogenic panel of human breast cancer cells derived from MDA‐MB‐231 cells. It was observed that cells after lung metastasis have the fastest migration and lowest stiffness, with a significantly higher capacity to transition into an amoeboid mode. Our findings illustrate that metastasis is a selective process favoring motile and softer cells. Moreover, the observation that circulating tumor cells resemble the parental cell line, but not lung‐metastatic cells, suggests that cells with higher deformability and motility are likely selected during extravasation and colonization.