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Phellinus linteus polysaccharide extract improves insulin resistance by regulating gut microbiota composition
Author(s) -
Liu Yangyang,
Wang Chaorui,
Li Jinshan,
Li Tiantian,
Zhang Yong,
Liang Yunxiang,
Mei Yuxia
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.201901943rr
Subject(s) - phellinus linteus , gut flora , polysaccharide , insulin resistance , prebiotic , metformin , insulin , type 2 diabetes , chemistry , biology , pharmacology , endocrinology , microbiology and biotechnology , diabetes mellitus , medicine , food science , biochemistry , botany , mycelium
The hypoglycemic effect of Phellinus linteus polysaccharide extract (PLPE) has been documented in several previous studies, but the functional interactions among PLPE, gut microbiota, and the hypoglycemic effect remain unclear. We examined the regulatory effect of PLPE on gut microbiota, and the molecular mechanism underlying improvement of insulin resistance, using a type 2 diabetic rat model. Here, 24 male Sprague‐Dawley rats were randomly divided into four groups that were subjected to intervention of saline (normal and model control group), metformin (120 mg/kg.bw), and PLPE (600 mg/kg.bw) by oral administration. After 8 weeks of treatment, PLPE increased levels of short‐chain fatty acids (SCFAs) by enhancing abundance of SCFA‐producing bacteria. SCFAs maintained intestinal barrier function and reduced lipopolysaccharides content in blood, thereby helping to reduce systemic inflammation and reverse insulin resistance. Our findings suggest that PLPE (in which polysaccharides are the major component) has potential application as a prebiotic for regulating gut microbiota composition in diabetic patients.