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Differential role of interleukin‐1β in neuroinflammation‐induced impairment of spatial and nonspatial memory in hyperammonemic rats
Author(s) -
TaoroGonzález Lucas,
CabreraPastor Andrea,
SanchoAlonso María,
Arenas Yaiza M.,
MeseguerEstornell Fernando,
Balzano Tiziano,
Elmlili Nisrin,
Felipo Vicente
Publication year - 2019
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.201900230rr
Subject(s) - perirhinal cortex , neuroinflammation , hippocampus , neuroscience , memory impairment , psychology , prefrontal cortex , effects of stress on memory , microglia , medicine , recognition memory , cognition , inflammation , memory consolidation
Activated microglia and increased brain IL‐1β play a main role in cognitive impairment in much pathology. We studied the role of IL‐1β in neuroinflammation‐induced impairment of the following different types of learning and memory: novel object recognition (NOR), novel object location (NOL), spatial learning, reference memory (RM), and working memory (WM). All these processes are impaired in hyperammonemic rats. We assessed which of these types of learning and memory are restored by blocking the IL‐1 receptor in vivo in hyperammonemic rats and the possible mechanisms involved. Blocking the IL‐1 receptor reversed microglial activation in the hippocampus, perirhinal cortex, and prefrontal cortex but not in the postrhinal cortex. This was associated with the restoration of NOR and WM but not of tasks involving a spatial component (NOL and RM). This suggests that IL‐1β would be involved in neuroinflammation‐induced nonspatial memory impairment, whereas spatial memory impairment would be IL‐1β–independent and would be mediated by other proinflammatory factors.—Taoro‐González, L., Cabrera‐Pastor, A., Sancho‐Alonso, M., Arenas, Y. M., Meseguer‐Estornell, F., Balzano, T., ElMlili, N., Felipo, V. Differential role of interleukin‐1β in neuroinflammation‐induced impairment of spatial and nonspatial memory in hyperammonemic rats. FASEB J. 33, 9913–9928 (2019). www.fasebj.org