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Ophiopogonin D alleviates high‐fat diet‐induced metabolic syndrome and changes the structure of gut microbiota in mice
Author(s) -
Chen Siyu,
Li Xiao,
Liu Li,
Liu Chang,
Han Xiao
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.201700741rr
Subject(s) - gut flora , metabolic syndrome , medicine , endocrinology , obesity , immunology
Gut dysbiosis is believed to play a critical role in the pathogenesis of metabolic diseases, including obesity. Ophiopogonin D (OP‐D), a steroidal glycoside and an active component extracted from the root of the plant Ophiopogon japonicus (also known as radix ophiopogonis), can regulate multiple physiologic processes. Here we show that OP‐D administration reduces body weight, hyperglycemia, hyperlipidemia, and insulin resistance in male mice fed a high‐fat diet (HFD). Pyrosequencing of the V4 regions of 16S rRNA genes in mouse feces revealed a deviation of the gut microbiota in response to OP‐D treatment. In particular, the decreased Firmicutes‐to‐Bacteroidetes ratios and endotoxin‐bearing Proteobacteria levels indicated that OP‐D reversed HFD‐induced gut dysbiosis. More importantly, the effects of OP‐D on modulation of obesity and microbiota were transferable via horizontal feces transfer from OP‐D‐treated mice to HFD‐fed mice. Taken together, our results suggest that OP‐D may be used as a prebiotic agent to treat obesity‐associated gut dysbiosis and metabolic syndrome.—Chen, S., Li, X., Liu, L., Liu, C., Han, X. Ophiopogonin D alleviates high‐fat diet‐induced metabolic syndrome and changes the structure of gut microbiota in mice. FASEB J. 32,1139‐1153 (2018). www.fasebj.org