Premium
Oral sodium butyrate impacts brain metabolism and hippocampal neurogenesis, with limited effects on gut anatomy and function in pigs
Author(s) -
ValLaillet David,
Guérin Sylvie,
Coquery Nicolas,
Nogret Isabelle,
Formal Michèle,
Romé Véronique,
Le Normand Laurence,
Meurice Paul,
Randuineau Gwénaëlle,
Guilloteau Paul,
Malbert CharlesHenri,
Parnet Patricia,
Lallès JeanPaul,
Segain JeanPierre
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.201700547rr
Subject(s) - sodium butyrate , medicine , endocrinology , neurogenesis , hippocampal formation , neun , butyrate , biology , chemistry , biochemistry , immunohistochemistry , neuroscience , gene , fermentation
Butyrate can improve gut functions, whereas histone deacetylase inhibitors might alleviate neuro‐cognitive alterations. Our aim was to assess whether oral butyrate could modulate brain metabolism and plasticity and if this would relate to gut function. Sixteen pigs were subjected to sodium butyrate (SB) supplementation via beverage water or water only [control (C)]. All pigs had blood sampled after 2 and 3 wk of treatment, and were subjected to a brain positron emission tomography after 3 wk. Animals were euthanized after 4 wk to sample pancreas, intestine, and brain for gut physiology and anatomy measurements, as well as hippocampal histology, Ki67, and doublecortin (DCX) immunohistochemistry. SB compared with C treatment triggered basal brain glucose metabolism changes in the nucleus accumbens and hippocampus ( P = 0.003), increased hippocampal granular cell layer volume ( P = 0.006), and neurogenesis (Ki67: P = 0.026; DCX: P = 0.029). After 2 wk of treatment, plasma levels of glucose, insulin, lactate, glucagon‐like peptide 1, and peptide tyrosine tyrosine remained unchanged. After 3 wk, plasma levels of lactate were lower in SB compared with C animals ( P = 0.028), with no difference for glucose and insulin. Butyrate intake impacted very little gut anatomy and function. These results demonstrate that oral SB impacted brain functions with little effects on the gut.— Val‐Laillet, D., Guérin, S., Coquery, N., Nogret, I., Formal, M., Romé, V., Le Normand, L., Meurice, P., Randuineau, G., Guilloteau, P., Malbert, C.‐H., Parnét, P., Lallés, J.‐P., Segain, J.‐P. Oral sodium butyrate impacts brain metabolism and hippocampal neurogenesis, with limited effects on gut anatomy and function in pigs. FASEB J. 32, 2160–2171 (2018). www.fasebj.org