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Omega‐3 polyunsaturated fatty acids promote amyloid‐β clearance from the brain through mediating the function of the glymphatic system
Author(s) -
Ren Huixia,
Luo Chuanming,
Feng Yanqing,
Yao Xiaoli,
Shi Zhe,
Liang Fengyin,
Kang Jing X.,
Wan JianBo,
Pei Zhong,
Su Huanxing
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.201600896
Subject(s) - glymphatic system , polyunsaturated fatty acid , extracellular , chemistry , genetically modified mouse , transgene , medicine , biochemistry , fatty acid , gene , cerebrospinal fluid
Impairment of amyloid‐β (Aβ) clearance leads to Aβ accumulation in the brain during the development of Alzheimer's disease (AD). Strategies that can restore or improve the clearance function hold great promise in delaying or preventing the onset of AD. Here, we show that n‐3 polyunsaturated fatty acids (PUFAs), by use of fat ‐ 1 transgenicmice andoral administration of fish oil, significantly promote interstitial Aβ clearance from theb rain and resist Aβ injury. Such beneficial effects were abolished in Aqp4 ‐knockout mice, suggesting that the AQP4‐ dependent glymphatic system is actively involved in the promoting the effects of n‐3 PUFAs on the clearance of extracellularAβ. Imaging on clarified brain tissues clearly displayed thatn‐3 PUFAsmarkedly inhibit the activation of astrocytes and protect the AQP4 polarization in the affected brain region after Aβ injection. The results of the present study prove a novelmechanism by which n‐3 PUFAs exert protective roles in reducingAβ accumulation via mediating the glymphatic system function.—Ren, H., Luo, C., Feng, Y., Yao, X., Shi, Z., Liang, F., Kang, J. X., Wan, J.‐B., Pei, Z., Su, H. Omega‐3 polyunsaturated fatty acids promote amyloid‐β clearance from the brain through mediating the function of the glymphatic system. FASEB J. 31, 282–293 (2017) www.fasebj.org