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Wnt/β‐catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration
Author(s) -
Bastakoty Dikshya,
Young Pampee P.
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.201600502r
Subject(s) - wnt signaling pathway , regeneration (biology) , catenin , fibrosis , biology , embryonic stem cell , beta catenin , microbiology and biotechnology , pathology , medicine , signal transduction , genetics , gene
The Wnt/β‐catenin pathway is an evolutionarily conserved set of signals with critical roles in embryonic and neonatal development across species. In mammals the pathway is quiescent in many organs. It is reactivated in response to injury and is reported to play complex and contrasting roles in promoting regeneration and fibrosis. We review the current understanding of the role of the Wnt/β‐catenin pathway in injury of various mammalian organs and discuss the current advances and potential of Wnt inhibitory therapeutics toward promoting tissue regeneration and reducing fibrosis.—Bastakoty, D., Young, P. P. Wnt/β‐catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration. FASEB J. 30, 3271–3284 (2016). www.fasebj.org