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Rutin ameliorates obesity through brown fat activation
Author(s) -
Yuan Xiaoxue,
Wei Gang,
You Yilin,
Huang Yuanyuan,
Lee Hyuek Jong,
Dong Meng,
Lin Jun,
Hu Tao,
Zhang Hanlin,
Zhang Chuanhai,
Zhou Huiqiao,
Ye Rongcai,
Qi Xiaolong,
Zhai Baiqiang,
Huang Weidong,
Liu Shunai,
Xie Wen,
Liu Qingsong,
Liu Xiaomeng,
Cui Chengbi,
Li Donghao,
Zhan Jicheng,
Cheng Jun,
Yuan Zengqiang,
Jin Wanzhu
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.201600459rr
Subject(s) - rutin , brown adipose tissue , endocrinology , medicine , chemistry , adipose tissue , thermogenin , adipocyte , thermogenesis , obesity , pharmacology , biochemistry , antioxidant
Increasing energy expenditure through activation of brown adipose tissue (BAT) is a critical approach to treating obesity and diabetes. In this study, rutin, a natural compound extracted frommulberry and a drug used as a capillary stabilizer clinically formany years without any side effects, regulated whole‐body energymetabolism by enhancing BAT activity. Rutin treatment significantly reduced adiposity, increased energy expenditure, and improved glucose homeostasis in both genetically obese (Db/Db) and diet‐induced obesity (DIO) mice. Rutin also induced brown‐like adipocyte (beige) formation in subcutaneous adipose tissue in both obesity mouse models. Mechanistically, we found that rutin directly bound to and stabilized SIRT1, leading to hypoacetylation of peroxisome proliferator‐activated receptor γ coactivator‐1α protein, which stimulated Tfam transactivation and eventually augmented the number of mitochondria and UCP1 activity in BAT. These findings reveal that rutin is a novel small molecule that activates BAT and may provide a novel therapeutic approach to the treatment of metabolic disorders.—Yuan, X., Wei, G., You, Y., Huang, Y., Lee, H. J., Dong, M., Lin, J., Hu, T., Zhang, H., Zhang, C., Zhou, H., Ye, R., Qi, X., Zhai, B., Huang, W., Liu, S., Xie, W., Liu, Q., Liu, X., Cui, C., Li, D., Zhan, J., Cheng, J., Yuan, Z., Jin, W. Rutin ameliorates obesity through brown fat activation. FASEB J. 31, 333–345 (2017) www.fasebj.org