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Protein malnutrition blunts the increment of taurine transporter expression by a high‐fat diet and impairs taurine reestablishment of insulin secretion
Author(s) -
Branco Renato Chaves Souto,
Camargo Rafael Ludemann,
Batista Thiago Martins,
Vettorazzi Jean Franciesco,
Borck Patrícia Cristine,
SantosSilva Junia Carolina Rebelo,
Boschero Antonio Carlos,
Zoppi Cláudio Cesar,
Carneiro Everardo Magalhães
Publication year - 2017
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.201600326rrr
Subject(s) - medicine , endocrinology , taurine , insulin , pancreatic islets , weaning , biology , mitochondrial biogenesis , chemistry , islet , mitochondrion , biochemistry , amino acid
Taurine (Tau) restores β‐cell function in obesity; however, its action is lost in malnourished obese rodents. Here, we investigated the mechanisms involved in the lack of effects of Tau in this model. C57BL/6 mice were fed a control diet (CD)(14% protein) oraprotein‐restricted diet (RD) (6% protein) for 6 wk. Afterward, mice received a high‐fat diet (HFD) for 8 wk [CD + HFD (CH) and RD + HFD (RH)] with or without 5% Tau supplementation after weaning on their drinking water [CH + Tau (CHT) and RH + Tau (RHT)]. The HFD increased insulin secretion through mitochondrial metabolism in CH and RH. Tau prevented all those alterations in CHT only. The expression of the taurine transporter (Tau‐T), as well as Tau content in pancreatic islets, was increased in CH but had no effect on RH. Protein malnutrition programs β cells and impairs Tau‐induced restoration of mitochondrial metabolism and biogenesis. This may be associated with modulation of the expression of Tau‐T in pancreatic islets, which may be responsible for the absence of effect of Tau in protein‐malnourished obese mice.—Branco, R.C. S., Camargo, R. L., Batista, T. M., Vettorazzi, J. F., Borck, P. C., dos Santos‐Silva, J. C. R., Boschero, A. C., Zoppi, C. C., Carneiro, E. M. Protein malnutrition blunts the increment of taurine transporter expression by a high‐fat diet and impairs taurine reestablishment of insulin secretion. FASEB J. 31, 4078–4087 (2017). www.fasebj.org —Branco, Renato Chaves Souto, Camargo, Rafael Ludemann, Batista, Thiago Martins, Vettorazzi, Jean Franciesco, Borck, Patrícia Cristine, dos Santos‐Silva, Junia Carolina Rebelo, Boschero, Antonio Carlos, Zoppi, Cláudio Cesar, Carneiro, Everardo Magalhães Protein malnutrition blunts the increment of taurine transporter expression by a high‐fat diet and impairs taurine reestablishment of insulin secretion. FASEB J. 31, 4078–4087 (2017)