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The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease?
Author(s) -
Deckx Sophie,
Heymans Stephane,
Papageorgiou AnnaPia
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.201500096r
Subject(s) - regulator , disease , medicine , biology , genetics , gene
Small leucine‐rich proteoglycans are emerging as important regulatory proteins within the extracellular matrix, where they exert both structural and nonstructural functions and hence are modulators of numerous biological processes, such as inflammation, fibrosis, and cell proliferation. One proteoglycan in particular, osteoglycin (OGN), also known as mimecan, shows great structural and functional diversity in normal physiology and in disease states, therefore making it a very interesting candidate for the development of novel therapeutic strategies. Unfortunately, the literature on OGN is confusing, as it has different names, and different transcript and protein variants have been identified. This review will give a clear overview of the different structures and functions of OGN that have been identified to date, portray its central role in pathophysiology, and highlight the importance of posttranslational processing, such as glycosylation, for the diversity of its functions.—Deckx, S., Heymans, S., Papageorgiou, A.‐P. The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease? FASEB J. 30, 2651‐2661 (2016). www.fasebj.org