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Connecting the nucleolus to the cell cycle and human disease
Author(s) -
Tsai Robert Y. L.,
Pederson Thoru
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.14-254680
Subject(s) - nucleolus , cell cycle , ribosome , cell , cell cycle progression , biology , microbiology and biotechnology , cell growth , neuroscience , rna , genetics , gene , cytoplasm
Long known as the center of ribosome synthesis, the nucleolus is connected to cell cycle regulation in more subtle ways. One is a surveillance system that reacts promptly when rRNA synthesis or processing is impaired, halting cell cycle progression. Conversely, the nucleolus also acts as a first‐responder to growth‐related stress signals. Here we review emerging concepts on how these “infraribosomal” links between the nucleolus and cell cycle progression operate in both forward and reverse gears. We offer perspectives on how new cancer therapeutic designs that target this infraribosomal mode of cell growth control may shape future clinical progress.—Tsai, R. Y. L., Pederson, T. Connecting the nucleolus to the cell cycle and human disease. FASEB J. 28, 3290–3296 (2014). www.fasebj.org