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The Evolution of Vertebrate Blood Clotting by
Author(s) -
Loscalzo Joseph
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.14-0502ufm
Subject(s) - medical school , citation , courtesy , library science , medicine , sociology , medical education , law , computer science , political science
Hemostasis is an essential physiological response to acute injury in organisms with a circulatory system. In the Darwinian struggle that drove early natural selection, only creatures that were capable of limiting blood loss could survive wounds or injuries that breeched a vessel. Vertebrates, from hagfish to primates, suffer acute injuries that would lead to exsanguination were adequate hemostasis not in place. The clotting of blood in response to injury is a primordial\ but highly efficient and complex affair, the analysis of which remains a challenge.