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Resistance training restores muscle sex steroid hormone steroidogenesis in older men
Author(s) -
Sato Koji,
Iemitsu Motoyuki,
Matsutani Kenji,
Kurihara Toshiyuki,
Hamaoka Takafumi,
Fujita Satoshi
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.13-245480
Subject(s) - resistance training , endocrinology , hormone , medicine , steroid , sex steroid , steroid hormone
Skeletal muscle can synthesize testosterone and 5α‐dihydrotestosterone (DHT) from dehydro‐epiandrosterone (DHEA) via steroidogenic enzymes in vitro , but hormone levels and steroidogenic enzyme expression decline with aging. Resistance exercise has been shown to increase in plasma sex steroid hormone levels. However, it remains unclear whether resistance training can restore impaired steroidogenic enzyme expressions in older individuals. Six young and 13 older men were recruited, and muscle biopsies were taken from the vastus lateralis at basal state. The same group of older subjects underwent resistance training involving knee extension and flexion exercises for 12 wk, and post‐training biopsies were performed 4–5 d after the last exercise session. Muscular sex steroid hormone levels and sex steroidgenesis‐related enzyme expressions were significantly lower in older subjects than younger ones at baseline, but 12 wk of resistance training significantly restored hormone levels (DHEA: 432±26 at baseline, 682±31 pg/μg protein, DHT: 6.2±0.9 at baseline, 9.8±1.4 pg/μg protein). Furthermore, the steroidogenesis‐related enzymes such as 3β‐hydroxysteroid dehydrogenase (HSD), 17β‐HSD, and 5α‐reductase expressions were significantly restored by resistance training. We conclude progressive resistance training restores age‐related declines in sex steroidogenic enzyme and muscle sex steroid hormone levels in older men.—Sato, K., Iemitsu, M., Matsutani, K., Kurihara, T., Hamaoka, T., Fujita, S. Resistance training restores muscle sex steroid hormone steroidogenesis in older men. FASEB J. 28, 1891–1897 (2014). www.fasebj.org