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Two sides of the same coin: stem cells in cancer and regenerative medicine
Author(s) -
Ilmer Matthias,
Vykoukal Jody,
Boiles Alejandro Recio,
Coleman Michael,
Alt Eckhard
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.13-244640
Subject(s) - regenerative medicine , stromal cell , stem cell , mesenchymal stem cell , cancer cell , cancer , bone marrow , cancer research , adipose tissue , biology , cancer stem cell , tissue engineering , medicine , immunology , microbiology and biotechnology , genetics
Multipotent stromal cells (MSCs) derived from bone marrow, adipose tissue, cord blood, and other origins have recently received much attention as potential therapeutic agents with beneficial immunomodulatory and regenerative properties. In their native tissue environment, however, such cells also appear to have essential functions in building and supporting tumor microenvironments, providing metastatic niches, and maintaining cancer hallmarks. Here, we consider the varied roles of these tissue‐resident stroma‐associated cells, synthesize recent and emerging discoveries, and discuss the role, potential, and clinical applications of MSCs in cancer and regenerative medicine.—Ilmer, M., Vykoukal, J., Recio Boiles, A., Coleman, M., Alt, E. Two sides of the same coin: stem cells in cancer and regenerative medicine. FASEB J . 28, 2748–2761 (2014). www.fasebj.org