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Epidermal expression of I‐TAC (Cxc111) instructs adaptive Th2‐type immunity
Author(s) -
Roebrock Kirsten,
Sunderkotter Cord,
Münck NielsArne,
Wolf Marc,
Nippe Nadine,
Barczyk Katarzyna,
Varga Georg,
Vogl Thomas,
Roth Johannes,
Ehrchen Jan
Publication year - 2014
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.13-233593
Subject(s) - acquired immune system , expression (computer science) , immunity , biology , immunology , immune system , computer science , programming language
To decipher early promoters of the local microenvironment for Th2‐type immunity, we wanted to identify gene patterns that were induced by Leishmania major in the infected skin of susceptible, Th2‐prone BALB/c, but not of resistant, Th1‐prone C57BL/6 mice. We found a marked up‐regulation of the chemokine I‐TAC (Cxc111) during the first 2 d of infection in the epidermis of susceptible but not of resistant mice. Accordingly, local injection of I‐TAC (2×1 μg) in resistant mice on the first day of infection resulted in a Th2‐driven, sustained deterioration of disease and dramatically enhanced parasite levels. On the cellular level, I‐TAC decreased IL‐12 production by dendritic cells (DCs) in skin‐draining lymph nodes and by DCs in vitro . Thus, we demonstrate for the first time that epidermis‐derived I‐TAC triggers a sustained Th2‐response that determines the outcome of a complex immunological process.—Roebrock, K., Sunderkotter, C., Münck, N‐A., Wolf, M., Nippe, N., Barczyk, K., Varga, G., Vogl, T., Roth, J., Ehrchen, J. Epidermal expression of I‐TAC (Cxc111) instructs adaptive Th2‐type immunity. FASEB J. 28, 28–1724 (1734). www.fasebj.org