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Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease
Author(s) -
Michel Patrick P.,
Toulorge Damien,
Guerreiro Serge,
Hirsch Etienne C.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.12-220418
Subject(s) - substantia nigra , neurodegeneration , neuroscience , dopamine , dopaminergic , parkinson's disease , disease , stimulation , deep brain stimulation , biology , medicine
Parkinson disease (PD) is a degenerative brain disorder characterized by motor symptoms that are unequivocally associated with the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Although our knowledge of the mechanisms that contribute to DA cell death in both hereditary and sporadic forms of the disease has advanced significantly, the nature of the pathogenic process remains poorly understood. In this review, we present evidence that neurodegeneration occurs when the electrical activity and excitability of these neurons is reduced. In particular, we will focus on the specific need these neurons may have for stimulation in order to survive and on the molecular and cellular mechanisms that may be compromised when this need is no longer met in PD.— Michel, P. P., Toulorge, D., Guerreiro, S., Hirsch, E. C., Specific needs of dopamine neurons for stimulation in order to survive: implication for Parkinson disease. FASEB J. 27, 3414–3423 (2013). www.fasebj.org