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Remembering one's identity: the epigenetic basis of stem cell fate decisions
Author(s) -
Sen George L.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.11-182774
Subject(s) - epigenome , multicellular organism , epigenetics , stem cell , biology , organism , cell fate determination , adult stem cell , microbiology and biotechnology , cellular differentiation , genetics , cell , dna methylation , transcription factor , gene , gene expression
Stem cells serve a vital role in multicellular organisms by constantly replenishing tissue with their differentiated progeny during normal homeostasis or damage. How these cells maintain their identities throughout the life of an organism is an area of intense research. In this review, we explore recent emerging evidence that stem cell fate decisions are based on their epigenome and specific epigenetic factors.—Sen, G. L. Remembering one's identity: the epigenetic basis of stem cell fate decisions. FASEB J. 25, 2123‐2128 (2011). www.fasebj.org