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Short‐term consumption of a high‐fat diet impairs whole‐body efficiency and cognitive function in sedentary men
Author(s) -
Edwards Lindsay M.,
Murray Andrew J.,
Holloway Cameron J.,
Carter Emma E.,
Kemp Graham J.,
Codreanu Ion,
Brooker Helen,
Tyler Damian J.,
Robbins Peter A.,
Clarke Kieran
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.10-171983
Subject(s) - ucp3 , endocrinology , medicine , uncoupling protein , skeletal muscle , zoology , chemistry , biology , obesity , brown adipose tissue
We recently showed that a short‐term high‐fat diet blunted exercise performance in rats, accompanied by increased uncoupling protein levels and greater respiratory uncoupling. In this study, we investigated the effects of a similar diet on physical and cognitive performance in humans. Twenty sedentary men were assessed when consuming a standardized, nutritionally balanced diet (control) and after7dof consuming a diet comprising 74% kcal from fat. Efficiency was measured during a standardized exercise task, and cognition was assessed using a computerized assessment battery. Skeletal muscle mitochondrial function was measured using 31 P magnetic resonance spectroscopy. The diet increased mean ± se plasma free fatty acids by 44% (0.32±0.03 vs. 0.46±0.05 mM; P<0.05) and decreased whole‐body efficiency by 3% (21±1 vs. 18±1%;P<0.05), although muscle uncoupling protein (UCP3) content and maximal mitochondrial function were unchanged. High‐fat diet consumption also increased subjects’ simple reaction times (P<0.01) and decreased power of attention (P<0.01). Thus, we have shown that a high‐fat diet blunts whole‐body efficiency and cognition in sedentary men. We suggest that this effect may be due to increased respiratory uncoupling.—Edwards, L. M., Murray, A. J., Holloway, C. J., Carter, E. E., Kemp, G. J., Codreanu, I., Brooker, H., Tyler, D. J. Tyler, Robbins, P. A., Clarke, K. Short‐term consumption of a high‐fat diet impairs whole‐body efficiency and cognitive function in sedentary men. FASEB J. 25, 1088–1096 (2011). www.fasebj.org