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Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk
Author(s) -
Kivela Riikka,
Silvennoinen Mika,
Lehti Maarit,
RinnankoskiTuikka Rita,
Purhonen Tatja,
Ketola Tarmo,
Pullinen Katri,
Vuento Meri,
Mutanen Niina,
Sartor Maureen A.,
Reunanen Hilkka,
Koch Lauren G.,
Britton Steven L.,
Kainulainen Heikki
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.10-157313
Subject(s) - aerobic capacity , skeletal muscle , vo2 max , endurance training , medicine , endocrinology , gene expression , biology , aerobic exercise , phenotype , oxidative phosphorylation , metabolic syndrome , disease , gene , genetics , biochemistry , diabetes mellitus , heart rate , blood pressure
A strong link exists between low aerobic exercise capacity and complex metabolic diseases. To probe this linkage, we utilized rat models of low and high intrinsic aerobic endurance running capacity that differ also in the risk for metabolic syndrome. We investigated in skeletal muscle gene‐phenotype relationships that connect aerobic endurance capacity with metabolic disease risk factors. The study compared 12 high capacity runners (HCRs) and 12 low capacity runners (LCRs) from generation 18 of selection that differed by 615% for maximal treadmill endurance running capacity. On average, LCRs were heavier and had increased blood glucose, insulin, and triglycerides compared with HCRs. HCRs were higher for resting metabolic rate, voluntary activity, serum high density lipoproteins, muscle capillarity, and mitochondrial area. Bioinformatic analysis of skeletal muscle gene expression data revealed that many genes up‐regulated in HCRs were related to oxidative energy metabolism. Seven mean mRNA expression centroids, including oxidative phosphorylation and fatty acid metabolism, correlated significantly with several exercise capacity and disease risk phenotypes. These expression‐phenotype correlations, together with diminished skeletal muscle capillarity and mitochondrial area in LCR rats, support the general hypothesis that an inherited intrinsic aerobic capacity can underlie disease risks.—Kivelä, R., Silvennoinen, M., Lehti, M., Rinnankoski‐Tuikka, R., Purhonen, T., Ketola, T., Pullinen, K., Vuento, M., Mutanen, N., Sartor, M. A., Reunanen, H., Koch, L. G., Britton, S. L., Kainulainen, H. Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk. FASEB J . 24, 4565–4574 (2010). www.fasebj.org