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Human CD4 8 T cells are a distinctive immunoregulatory subset
Author(s) -
Huang MeiChuan,
Patel Kalpesh,
Taub Dennis D.,
Longo Dan L.,
Goetzl Edward J.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.09-153148
Subject(s) - immunology , natural killer t cell , cytotoxic t cell , cytokine , cd8 , t cell , interleukin 21 , biology , il 2 receptor , immunity , microbiology and biotechnology , immune system , in vitro , biochemistry
Human CD4 − 8 − T cells are a minor subset quantitatively but potentially important in immunity because they are predominantly distributed at body surfaces, and their number and activities increase in autoimmune diseases and decrease with aging. Distinguishing characteristics of CD4 − 8 − T cells are found to include a unique profile of cytokines, including Serpin E1, which is not generated by other T cells, MIF, and TGF‐ß. At 2–5% of the total in mixtures with CD4 + CD8 T cells, CD4 − 8 − T cells enhance the generation of IFN‐γ and IL‐17 by up to 12‐ and 5‐fold, respectively, without contributing either cytokine or affecting cytokine production by NK/NKT cells. CD4 − 8 − T cellderived MIF is their major enhancer and TGFß their principal inhibitor of CD4 and CD8 T cell cytokine production. Decreases in CD4 − 8 − T cell effects may diminish protective immunity in aging, whereas increases may augment the severity of autoimmune diseases.—Huang, M.‐C, Patel, K., Taub, D. D., Longo, D. L, Goetzl, E. J. Human CD4 − 8 − T cells are a distinctive immunoregulatory subset. FASEB J. 24, 2558–2566 (2010). www.fasebj.org