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SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age‐related neoplasms
Author(s) -
Jung-Hynes Brittney,
Ahmad Nihal
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.09-129148
Subject(s) - circadian rhythm , circadian clock , biological clock , connection (principal bundle) , biology , neuroscience , medicine , mathematics , geometry
Aging is believed to be a primary risk factor for cancer. Interestingly, the sirtuin family of class III histone deacetylases (HDACs) has been implicated in the regulation of longevity and may be a lost link between aging and cancer. SIRT1, a nicotinamide adenine dinucleotide (NAD + )‐dependent sirtuin, has been shown to promote cell survival by inhibiting apoptosis or cellular senescence in mammalian cells. Recent studies have provided a link between the cellular metabolic function of SIRT1 and the circadian rhythm (controlled by a clock machinery), which, if deregulated, may lead to an increased risk for some cancers. Interestingly, the loss of the pineal hormone melatonin, a known regulator of circadian rhythm, has been shown to cause deregulation in the circadian rhythm machinery and an increase in susceptibility to cancer. On the basis of scientific evidence, we propose a hypothesis that SIRT1 inhibition will impart an anti‐proliferative response in age‐related cancers via resynchronization of deregulated core clock circuitry at the cellular level. If this hypothesis is found valid, it may ultimately lead to the development of novel approaches toward management of age‐related malignancies and possibly other diseases.—Jung‐Hynes, B., Ahmad, N. SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age‐related neoplasms. FASEB J. 23, 2803–2809 (2009). www.fasebj.org