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Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy
Author(s) -
Klein J.,
Gonzalez J.,
Duchene J.,
Esposito L.,
Pradere J. P.,
Neau E.,
Delage C.,
Calise D.,
Ahluwalia A.,
Carayon P.,
Pesquero J. B.,
Bader M.,
Schanstra J. P.,
Bascands J. L.
Publication year - 2009
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fj.08-115600
Subject(s) - medicine , fibrosis , inflammation , kinin , proinflammatory cytokine , kidney , blockade , kidney disease , end stage renal disease , cancer research , endocrinology , immunology , receptor , disease , bradykinin
Renal fibrosis is the common histological feature of advanced glomerular and tubulointersti‐tial disease leading to end‐stage renal disease (ESRD). However' specific antifibrotic therapies to slow down the evolution to ESRD are still absent. Because persis‐tent inflammation is a key event in the development of fibrosis' we hypothesized that the proinflammatory kinin B1 receptor (B1R) could be such a new target. Here we show that' in the unilateral ureteral obstruction model of renal fibrosis' the B1R is overexpressed and that delayed treatment with an orally active non‐peptide B1R antagonist blocks macrophage infiltration' leading to a reversal of the level of renal fibrosis. In vivo bone marrow transplantation studies as well as in vitro studies on renal cells show that part of this antifibrotic mechanism of B1R blockade involves a direct effect on resident renal cells by inhibiting chemokine CCL2 and CCL7 expression. These findings suggest that blocking the B1R is a promising antifibrotic therapy.—Klein, J., Gonzalez, J., Duchene, J., Esposito, L., Pradere, J. P., Neau, E., Delage, C., Calise, D., Ahluwalia, A., Carayon, P., Pesquero, J. B., Bader, M., Schanstra, J. P., Bas‐cands, J. L. Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy. FASEBJ. 23′ 134‐142 (2009)